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KMID : 0363320000210030417
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 3 p.417 ~ p.424
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Effects of Sasim-tang Water Extract on Blood Pressure and Regional Cerebral Blood Flow Volume in Rats
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Lee Key-Sang
Lee Kwang-Gyu
Moon Byung-Soon
Lee In
Kim Jin-Su
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Abstract
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Objective : The purpose of this study was to investigate the effects of Sasim-tang water extract on the cardiovascular systems including changes of blood pressure and regional cerebral blood flow volume (rCBF) in male Sprague-Dawely rats.
Methods : The changes of blood pressure were recorded by data acquisition system composed of MacLab and Macintosh computer. The changes of rCBF were observed by Laser-Doppler flowmetry through a opened cranial window.
Results : 1. The changes of blood pressure was not affected by Sasim-tang extract intravenous injection in rats. 2. After pretreatment with propranolol(3mg/kg), L-NNA(10mg/kg) and 000(10mg/kg), the changes of blood pressure was not affected by Sasim tang extract intravenous injection in rats.
3. The changes of rCBF was increased in dose-dependent manner by Sasim-tang extract intravenous injection in rats.
4, After pretreatment with propranolol(3mg/kg), ODQ(10mg/kg) and L-NNA(10mg/kg), rCBF was significantly decreased in dose- dependent manner by Sasim-tang extract intravenous injection in rats.
Conclusions : These results suggest that Sasim-tang was related to the regulation of the sympathetic nerve system, nitric oxide synthesis and synthesis of cyclic GMP.
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KEYWORD
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blood pressure, Sasim-tang, regional cerebral blood flow volume(rCBF)
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